منابع مشابه
Reovirus-induced apoptosis is mediated by TRAIL.
Members of the tumor necrosis factor (TNF) receptor superfamily and their activating ligands transmit apoptotic signals in a variety of systems. We now show that the binding of TNF-related, apoptosis-inducing ligand (TRAIL) to its cellular receptors DR5 (TRAILR2) and DR4 (TRAILR1) mediates reovirus-induced apoptosis. Anti-TRAIL antibody and soluble TRAIL receptors block reovirus-induced apoptos...
متن کاملHuman mast cells undergo TRAIL-induced apoptosis.
Mast cells (MC), supposedly long-lived cells, play a key role in allergy and are important contributors to other inflammatory conditions in which they undergo hyperplasia. In humans, stem cell factor (SCF) is the main regulator of MC growth, differentiation, and survival. Although human MC numbers may also be regulated by apoptotic cell death, there have been no reports concerning the role of t...
متن کاملChemotherapy augments TRAIL-induced apoptosis in breast cell lines.
Expression and function of the TRAIL apoptotic pathway was investigated in normal and malignant breast epithelial cells. Glutathione-S-transferase (GST)-TRAIL extracellular domain fusion proteins were produced to analyze TRAIL-induced apoptosis. Only GST-TRAIL constructs containing regions homologous to the Fas self-association and ligand binding domains could induce apoptosis. GST-TRAIL induce...
متن کاملMarine Drugs: Modulation of TRAIL Induced Apoptosis in Cancer Cells
Cancer is a multifaceted and genomically complex disease. Research over decades has shown involvement of different biological mechanisms including suppression of tumor suppressor genes, overexpression of oncogenes, genetic/epigenetic mutations, intra-tumor heterogeneity, genomic instability and loss of apoptotic signaling network that signals through membrane death receptor-mediated intracellul...
متن کاملPotentiation of TRAIL-induced apoptosis in primary effusion lymphoma
http://bloodjournal.hematologylibrary.org/content/101/6/2321.full.html Updated information and services can be found at: (4217 articles) Neoplasia (3667 articles) Clinical Trials and Observations (746 articles) Apoptosis Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information ...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2009
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2009.04905.x